What is advil dosage

This low toxicity profile makes Advil a safe and effective pain reliever for multiple aches and pains. RX ibuprofen the active ingredient in Advil has a higher dosage than OTC and must be prescribed by a doctor. While no studies have shown a tolerance build up or weakening of pain relieving power , over-the-counter pain relievers including Advil should not be used for longer than 10 days unless directed by a physician.

Advil Liqui-Gels minis. Advil Easy Open Arthritis Cap. Advil Liqui-Gels. Advil PM Liqui-Gels. Infants' Advil Drops. Junior Strength Advil Chewables. Advil Allergy Sinus. All rights reserved. Do not exceed 2 tablets in 24 hours. Advil products for children under 12 years have different recommended doses and maximum limits per day depending on the age and weight of the child.

The active ingredient in Advil is ibuprofen, an NSAID non-steroidal anti-inflammatory drug that is a pain reliever and fever reducer. It is not necessary to take Advil with food. However, it may help to take it with food or milk if an upset stomach occurs. Consult your doctor before taking any analgesic if you have a sensitive stomach or a history of stomach problems such as heartburn, upset stomach or stomach pain.

Ibuprofen is the active ingredient in a range of over-the-counter OTC medicines. Body chemicals called prostaglandins produce pain and fever. Advil is an ibuprofen-based pain reliever brand that blocks the body's production of these prostaglandins, therefore reducing pain and fever. NSAIDs like ibuprofen are commonly used to manage mild to moderate pain such as headaches, migraine, period pain , inflammation redness and swelling and fever in both adults and children.

Consult your doctor before taking any analgesic, such as Advil, if you have a sensitive stomach or a history of stomach problems such as heartburn, upset stomach or stomach pain.

NSAIDs non-steroidal anti-inflammatory drug like ibuprofen, the active ingredient in Advil, are commonly used to manage period pain, also known as menstrual cramps or even period cramps.

Pain is typically felt as a muscle cramp in the stomach, which can often spread to the back and thighs. Learn more about period pain by reading up on our article through this link. Advil, containing the active ingredient, ibuprofen, can be used to manage mild to moderate pain, including back pain, muscle pain, arthritis, osteoarthritis and rheumatic pain. The active ingredient in Advil, ibuprofen, can be used to manage mild to moderate pain, such as a sore throat.

Learn more about sore throat pain here. NSAIDs like ibuprofen are commonly used to manage mild to moderate pain such as headaches, migraine, and period pain , inflammation redness and swelling and fever in both adults and children. Over-the-counter pain relievers Advil or otherwise should not be used for longer than a few days unless directed by a doctor. Ibuprofen can be used to manage mild to moderate pain, such as dental pain, as well as headaches, migraine, period pain, inflammation redness and swelling and fever in both adults and children.

GSK recommends that if you are taking other medications that you contact your doctor before commencing Advil. NSAIDs are commonly used to manage pain and inflammation swelling and redness associated with some common types of musculoskeletal disorders, and treat non-inflammatory conditions such as migraine and period pain, and to reduce fever. Ibuprofen is commonly used to provide temporary relief of pain, inflammation and discomfort from headache, migraine headache, tension headache, period pain, dental pain, minor arthritis pain, rheumatic pain, sore throat, sinus pain, and pain associated with the common cold and flu.

Advil can also cause easy bruising, prolonged bleeding from a cut, blood in the urine, and bleeding into the eye. Advil rarely causes allergies, producing symptoms including hives, facial swelling, asthma, skin rash, blisters, or shock.

Advil can increase the chances of developing kidney damage. This risk is enhanced in patients who are dehydrated or volume-depleted. If you have underlying kidney disease, such as due to diabetes, high blood pressure, or any other cause, please refrain from using Advil or another NSAID as much as possible. If you must take it, please make sure you are adequately hydrated. Advil can also decrease your blood sodium level and increase your blood potassium levels.

If you take blood pressure medications, which tend to raise blood potassium or reduce blood sodium levels, please refrain from taking Advil or another NSAID.

Advil can also cause volume overload, so if you take medications to get rid of extra water in your body, you should not take Advil. Advil can increase your risk of heart attack or stroke. The risk increases with higher dosages or prolonged use of Advil.

Aspirin, another NSAID, does not increase this risk—in fact, it is often used to reduce the risk of strokes and heart attacks. You should not take Advil just before or after having heart bypass surgery. Also, unless otherwise directed, pregnant women should not take Advil during their last trimester. Several factors increase the risk of bleeding with Advil. Do not use it if you have any of the following contraindications unless directed by your healthcare provider:.

Advil is one of the most commonly used over-the-counter medications. It is typically very safe, but there are risks. Be sure to follow directions and not to take more than the recommended dose. Discontinue use if pain gets worse or lasts more than 10 days. Discontinue use if no relief within 24 hours or if pain gets worse or lasts more than 3 days. In controlled analgesic clinical trials, doses more than mg were no more effective than the mg dose.

Discontinue use if fever gets worse or lasts more than 3 days. Discontinue use if no relief within 24 hours or if fever gets worse or lasts more than 3 days.

Guidelines classify ibuprofen as having established efficacy for the treatment of acute migraine. Guidelines recommend ibuprofen as an initial treatment option to reduce pain in children and adolescents with migraine. Max: mg PO 4 times daily. Guidelines suggest ibuprofen to inhibit harmful prostaglandins, which can cause vasoconstriction, dermal ischemia, and further tissues damage.

Specific guidelines for dosage adjustments in hepatic impairment are not available; it appears that no dosage adjustments are needed.

Avoid use of ibuprofen in patients with advanced renal disease unless the benefits are expected to outweigh the risks of worsening renal function. Prolonged therapy is not recommended. Shake well prior to use. Administer using an oral calibrated measuring device to ensure accurate dosing. Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit.

If visibly opaque particles, discolorations, or other foreign material are observed, do not use the solution. The patient must be well hydrated prior to administration to reduce the risk of renal adverse events. Intravenous infusion Infuse over at least 30 minutes for adults and over at least 10 minutes for pediatric patients. Storage: Diluted solutions are stable for 24 hours at ambient temperature approximately 20 to 25 degrees C and room lighting.

Generic: - Do not freeze - Store at controlled room temperature between 68 and 77 degrees F Advil: - Avoid excessive heat above degrees F - Store between 68 to 77 degrees F Advil Children's: - Do not freeze - Store between 68 to 77 degrees F Advil Children's Fever: - Do not freeze - Store between 68 to 77 degrees F Advil Infants': - Do not freeze - Store between 68 to 77 degrees F Advil Junior Strength: - Store between 68 to 77 degrees F Advil Migraine: - Avoid excessive heat above degrees F - Store between 68 to 77 degrees F Caldolor: - Discard product if it contains particulate matter, is cloudy, or discolored - Discard unused portion.

Do not store for later use. Ibuprofen is contraindicated in patients with salicylate hypersensitivity or NSAID hypersensitivity who have experienced asthma, urticaria, or other allergic reactions e.

Severe, rarely fatal, anaphylactoid reactions to ibuprofen have been reported. The triad typically occurs in patients with asthma who experience rhinitis with or without nasal polyps, or who experience severe, potentially fatal acute bronchospasm after taking aspirin or other NSAIDs.

The use of NSAIDs, including ibuprofen, may cause serious and potentially fatal skin reactions including exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis. Patients should be instructed to discontinue the medication and contact their health care provider if erythema, rash, blisters, or related skin reactions develop. Cautious use of ibuprofen is recommended in patients with asthma.

None of these children had exposure to ibuprofen prior to the study, and none experienced a decline in lung function after placebo. Use ibuprofen with caution in patients with hepatic disease. Severe hepatic reactions have occurred during treatment with ibuprofen, and patients with hepatic impairment are at an increased risk for developing these complications. Ibuprofen elimination may be prolonged in patients with hepatic impairment.

Discontinue ibuprofen if elevated hepatic enzymes persist or worsen, or if signs or symptoms of hepatic disease, such as jaundice, develop. In addition, patients with advanced liver disease are at increased risk for GI bleeding. Due to the role of prostaglandins in renal function and hemodynamics, patients with renal disease or heart failure should be closely monitored during ibuprofen therapy. Avoid ibuprofen use in patients with severe heart failure unless the benefits are expected to outweigh the risk of worsening heart failure.

Congestive heart failure and hypertension can be exacerbated by ibuprofen. A meta-analysis of randomized, controlled trials demonstrated an approximately 2-fold increase in hospitalizations for heart failure among non-selective and COX-2 selective-treated patients compared to placebo. In patients with hypertension, monitor blood pressure during the initiation of NSAID treatment and throughout therapy. A meta-analysis demonstrated that the effect of NSAIDs on blood pressure is the greatest in hypertensive individuals receiving antihypertensive medication.

Normotensive patients receiving antihypertensive therapy had higher increases in blood pressure than subjects with uncontrolled hypertension or normotensive subjects receiving no hypertensive therapy.

Patients with renal impairment, renal failure, hepatic disease, diabetes mellitus, systemic lupus erythematosus, or congestive heart failure, rheumatoid arthritis, edema, extracellular volume depletion i. Patients must be properly hydrated prior to administration of parenteral ibuprofen to reduce the risk of renal adverse events. Ibuprofen should be used cautiously in patients with preexisting hematological disease e. Ibuprofen should also be used with caution in patients undergoing surgery when a high degree of hemostasis is required.

NSAIDs should be used with caution in patients with immunosuppression or neutropenia. NSAIDs may mask the signs of infection such as fever or pain in patients with bone marrow suppression. Patients with coagulopathy are also at increased risk for GI bleeding. If ibuprofen therapy is undertaken in a geriatric patient, use the lowest effective ibuprofen dose for the shortest possible duration; monitor treatment closely. Due to body system frailties, geriatric patients are at an increased risk of NSAID-related adverse events.

Chronic use of ibuprofen can result in gastritis, ulceration with or without perforation, and GI bleeding, which can occur at any time, often without preceding symptoms. Patients of advanced age do not tolerate GI ulceration or bleeding well, and most cases of reported fatal GI events occur in this population. Elderly patients are also more prone to complications related to suboptimal renal perfusion and cardiovascular events. NSAIDs may cause new or worsening gastric and duodenal ulcers, and there is an increased risk of GI bleeding and peptic ulcer disease in high-risk groups including those above 75 years of age, or those taking oral or parenteral corticosteroids, anticoagulants, or antiplatelet medications.

The risk of ulcers, gross bleeding, or perforation is cumulative with continued use. Avoid the chronic use of NSAIDs in high-risk geriatric patients, unless other alternatives are not effective, and the patient can take a gastroprotective agent.

Avoid the use of NSAIDs in patients with a history of gastric or duodenal ulcers, unless other alternatives are not effective and the patient can take a gastroprotective agent. The use of a gastroprotective agent, like a proton pump inhibitor or misoprostol, reduces but does not eliminate, GI risks.

NSAIDs can also increase blood pressure and induce kidney injury. Use with caution in patients with asymptomatic heart failure. Also, NSAIDs may cause or worsen renal failure, increase blood pressure, or exacerbate heart failure.

Avoid ibuprofen use during the third trimester of pregnancy starting at 30 weeks of gestation due to the risk of premature closure of the fetal ductus arteriosus and persistent pulmonary hypertension in the neonate. If NSAID treatment is deemed necessary between 20 to 30 weeks of pregnancy, limit use to the lowest effective dose and shortest duration possible. Use of NSAIDs around 20 weeks gestation or later in pregnancy may cause fetal renal dysfunction leading to oligohydramnios, and in some cases, neonatal renal impairment.

These adverse outcomes are seen, on average, after days to weeks of treatment, although oligohydramnios has been infrequently reported as soon as 48 hours after NSAID initiation. Oligohydramnios is often, but not always, reversible with treatment discontinuation. Complications of prolonged oligohydramnios may include limb contractures and delayed lung maturation.

In some postmarketing cases of impaired neonatal renal function, invasive procedures such as exchange transfusion or dialysis were required. Observational data regarding embryofetal risks of NSAID use during the first trimester is inconclusive.

There are no adequate and well-controlled studies of ibuprofen in pregnant women. NSAIDs, such as ibuprofen, may pose a reproductive risk by delaying or preventing prostaglandin-mediated rupture of ovarian follicles, which has been associated with reversible infertility.

Consider withdrawal of NSAIDs in women who have difficulties conceiving or who are undergoing infertility evaluation. After oral administration, ibuprofen is present in breast milk at relative infant doses of 0. There are no reports of adverse effects on milk production or on the breast-fed infant. In a study of milk samples from 13 women who took an ibuprofen regimen of approximately 1 g daily, the relative infant dose was less than 0.

The relative infant dose was highest when the milk protein content was highest during the colostral phase. Patients with systemic lupus erythematosus SLE and related connective tissue diseases may be at increased risk of developing aseptic meningitis with fever and coma during ibuprofen therapy. This condition has been observed on rare occasions in patients on ibuprofen and has been reported in patients who do not have an underlying chronic disease.

If signs or symptoms of meningitis develop, consider the possibility that it is related to ibuprofen use. The manufacturer of clopidogrel advises that caution be used when used in combination with NSAIDs as an increase in occult GI blood loss occurred when clopidogrel was used concomitantly with naproxen Acebutolol: Moderate If nonsteroidal anti-inflammatory drugs NSAIDs and an antihypertensive drug are concurrently used, carefully monitor the patient for signs and symptoms of renal insufficiency and blood pressure control.

Doses of antihypertensive medications may require adjustment in patients receiving concurrent NSAIDs. NSAIDs, to varying degrees, have been associated with an elevation in blood pressure. This effect is most significant in patients receiving concurrent antihypertensive agents and long-term NSAID therapy. NSAIDs cause a dose-dependent reduction in prostaglandin formation, which may result in a reduction in renal blood flow leading to renal insufficiency and an increase in blood pressure that are often accompanied by peripheral edema and weight gain.

Patients who rely upon renal prostaglandins to maintain renal perfusion may have acute renal blood flow reduction with NSAID usage. Elderly patients may be at increased risk of adverse effects from combined long-term NSAID therapy and antihypertensive agents, especially diuretics, due to age-related decreases in renal function and an increased risk of stroke and coronary artery disease. Acetaminophen; Aspirin, ASA; Caffeine: Major Concomitant use of analgesic doses of aspirin with ibuprofen is generally not recommended due to the increased risk of bleeding, including GI bleeding.

The use of ibuprofen with other salicylates can also lead to additive GI toxicity. For patients taking low-dose aspirin for cardioprotection who require intermittent analgesics, consider the use of an NSAID that does not interfere with the antiplatelet effect of aspirin, or a non-NSAID analgesic.

After discontinuation of ibuprofen in patients taking low-dose aspirin, there may be an increased risk of cardiovascular events due to ibuprofen interference with the antiplatelet effect of aspirin. An in vitro study has shown that the antagonism of aspirin platelet inhibition probably involves competition at platelet-derived COX-1 and is related to the NSAIDs' ability to inhibit COX-1 mediated thromboxane B2 production in platelets. Clinically, the interaction may be more dramatic with routine as compared with intermittent ibuprofen usage.

Quantification of the risk was determined by the analysis of retrospective data, which may be inaccurate and incomplete. However, a trend towards a greater risk of a second myocardial infarction in the year after the initial event among adults taking daily aspirin was associated with a greater length of ibuprofen exposure. Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine: Major Concomitant use of analgesic doses of aspirin with ibuprofen is generally not recommended due to the increased risk of bleeding, including GI bleeding.

Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide: Major Concomitant use of analgesic doses of aspirin with ibuprofen is generally not recommended due to the increased risk of bleeding, including GI bleeding.

Acetohexamide: Moderate NSAIDs may enhance hypoglycemia in diabetic patients via inhibition of prostaglandin synthesis, which indirectly increases insulin secretion. If NSAIDs are administered or discontinued in patients receiving oral antidiabetic agents, patients should be monitored for hypoglycemia or loss of blood glucose control.

No clinically significant interaction between sulindac at daily doses of mg and oral hypoglycemic agents has been observed. Sulindac, its sulfide metabolite, and sulfonylureas are highly bound to protein. Sulindac could displace the sulfonylureas, altering hypoglycemic activity. Careful patient monitoring is recommended to ensure that no change in their diabetes medicine dosage is required.

A sulfonylurea dose adjustment may be needed, especially if sulindac doses greater than mg daily are used or if the drug combination is used in patients with renal impairment or other metabolic defects that might increase sulindac blood concentrations. Acyclovir: Moderate Monitor patients for signs of worsening renal function during coadministration of acyclovir and nonsteroidal antiinflammatory drugs.

Coadministration may increase the risk for drug-induced nephrotoxicity. Adefovir: Moderate Chronic coadministration of adefovir with nephrotoxic drugs, such as nonsteroidal antiinflammatory drugs may increase the risk of developing nephrotoxicity even in patients who have normal renal function.

The increase appears to be due to higher oral bioavailability, not a reduction in renal clearance of adefovir. Adefovir is efficiently transported by the human renal organic anion transporter 1, and the presence of this transporter appears to mediate the accumulation of the drug in renal proximal tubules. The in vitro study suggests that the use of a NSAID with adefovir may potentially reduce the nephrotoxic potential of adefovir.

Concurrent administration of drugs possessing nephrotoxic effects, such as nonsteroidal antiinflammatory agents NSAIDs , with Aldesleukin, IL-2 may increase the risk of kidney dysfunction. In addition, reduced kidney function secondary to Aldesleukin, IL-2 treatment may delay elimination of concomitant medications and increase the risk of adverse events from those drugs. Aliskiren: Moderate NSAIDs may attenuate the antihypertensive effects of aliskiren by inhibiting the synthesis of vasodilatory prostaglandins.

In patients who are elderly, volume-depleted including those on diuretic therapy , or with compromised renal function who are being treated with NSAIDs, the coadministration of aliskiren may result in a further deterioration of renal function, including acute renal failure. These effects are usually reversible.

Therefore, blood pressure and renal function should be monitored closely when an NSAID is administered to a patient taking aliskiren. Aliskiren; Amlodipine: Moderate NSAIDs may attenuate the antihypertensive effects of aliskiren by inhibiting the synthesis of vasodilatory prostaglandins. Among NSAIDs, indomethacin, naproxen, and piroxicam may have the greatest pressor effect, while the effects of sulindac and nabumetone may be significantly less.

In patients who are elderly, volume-depleted including those on diuretic therapy , or with compromised renal function who are being treated with NSAIDs, coadministration of angiotensin II receptor antagonists may result in further deterioration of renal function, including acute renal failure. Moderate NSAIDs may attenuate the antihypertensive effects of aliskiren by inhibiting the synthesis of vasodilatory prostaglandins.

Alpha-blockers: Moderate If nonsteroidal anti-inflammatory drugs NSAIDs and an antihypertensive drug are concurrently used, carefully monitor the patient for signs and symptoms of renal insufficiency and blood pressure control. Alteplase: Moderate NSAIDs can cause GI bleeding, inhibit platelet aggregation, prolong bleeding time; these pharmacodynamic effects may be increased when administered to patients receiving thrombolytic agents.

Patients receiving these drugs concurrently should be monitored closely for bleeding. Altretamine: Major Altretamine causes mild to moderate dose-related myelosuppression.

Due to the thrombocytopenic effects of altretamine, an additive risk of bleeding may be seen in patients receiving concomitant NSAIDs. Patients receiving concurrent NSAIDs should be monitored closely for symptoms of active or occult gastrointestinal bleeding. While NSAIDs appear to suppress microglial activity, which in turn may slow inflammatory neurodegenerative processes important for the progression of Alzheimer's disease AD , there are no clinical data at this time to suggest that NSAIDs alone or as combined therapy with AD agents result in synergistic effects in AD.

Amikacin: Moderate It is possible that additive nephrotoxicity may occur in patients who receive nonsteroidal antiinflammatory drugs NSAIDs concurrently with other nephrotoxic agents, such as amikacin. NSAIDS have been associated with an inhibition of prostaglandin synthesis, which may result in reduced renal blood flow leading to renal insufficiency and increases in blood pressure that are often accompanied by peripheral edema and weight gain.

If an NSAID and a diuretic are used concurrently, carefully monitor the patient for signs and symptoms of decreased renal function and diuretic efficacy.

Aminolevulinic Acid: Moderate Agents that inhibit prostaglandin synthesis such as nonsteroidal antiinflammatory drugs NSAIDs , could decrease the efficacy of photosensitizing agents used in photodynamic therapy. Aminosalicylate sodium, Aminosalicylic acid: Major Concomitant use of analgesic doses of aspirin with ibuprofen is generally not recommended due to the increased risk of bleeding, including GI bleeding.

Caution is recommended when administering amiodarone with CYP2C9 substrates including ibuprofen. The metabolism of ibuprofen may be decreased. Amlodipine; Benazepril: Moderate In the low-renin or volume-dependent hypertensive patient, prostaglandins play an important role in the hypotensive effects of ACE inhibitors. In patients who are elderly, volume-depleted including those on diuretic therapy , or with compromised renal function who are being treated with NSAIDs, the coadministration of ACE inhibitors may result in a further deterioration of renal function, including acute renal failure.

The potential clinical effects of selective or preferential COX-2 inhibitors are not known. Mean arterial blood pressure increased 3 mmHg in patients receiving ACE inhibitor benazepril 10 to 40 mg daily for 4 weeks with rofecoxib 25 mg once daily compared to the ACE inhibitor regimen alone.

Amphotericin B cholesteryl sulfate complex ABCD : Moderate Concurrent use of amphotericin B and other nephrotoxic medications, including nonsteroidal antiinflammatory drugs NSAIDs , may enhance the potential for drug-induced renal toxicity.

Monitor renal function carefully during concurrent therapy. Amphotericin B dosage reduction may be necessary if renal impairment occurs. Amphotericin B liposomal LAmB : Moderate Concurrent use of amphotericin B and other nephrotoxic medications, including nonsteroidal antiinflammatory drugs NSAIDs , may enhance the potential for drug-induced renal toxicity.

Amphotericin B: Moderate Concurrent use of amphotericin B and other nephrotoxic medications, including nonsteroidal antiinflammatory drugs NSAIDs , may enhance the potential for drug-induced renal toxicity. The manufacturer of clopidogrel advises that caution be used when used in combination with NSAIDs as an increase in occult GI blood loss occurred when clopidogrel was used concomitantly with naproxen Angiotensin II receptor antagonists: Moderate Nonsteroidal antiinflammatory drugs NSAIDs including selective COX-2 inhibitors may alter the response to Angiotensin II receptor blockers due to inhibition of vasodilatory prostaglandins.

Angiotensin-converting enzyme inhibitors: Moderate In the low-renin or volume-dependent hypertensive patient, prostaglandins play an important role in the hypotensive effects of ACE inhibitors.

Antithrombin III: Moderate An additive risk of bleeding may be seen in patients receiving anticoagulants in combination with other agents known to increase the risk of bleeding such as nonsteroidal antiinflammatory drugs NSAIDs.

Monitor clinical and laboratory response closely during concurrent use.